Behavior Phenotypes 

Advances in understanding behavioral phenotypes in neurogenetic syndromes, Harris 2010

The emerging DS behavioral phenotype in early childhood, Fidler 2005 

Measuring behavior in genetic disorders of MR, Hodapp and Dykens, 2005

Maladaptive Behavior   

Behavior and Adaptive Functioning in Adolescents With DS: Specifying Targets for Intervention, Jacola et al 2014

Problem behavior of individuals with DS in a nationwide cohort assessed in late adolescence, Van Gameren-Oosterom et al 2013

Development, Problem Behavior, and Quality of Life in a Population Based Sample of Eight-Year-Old Children with DS, Van Gameren-Oosterom et al 2011

Strategies to address challenging behaviour in young children with DS, Feeley et al 2008

Addressing challenging behaviour in children with DS: The use of applied behavior analysis for assessment and intervention, Feeley et al 2006

General

Pharmacotherapy of Down Syndrome, Palumbo et al 2018

Psychiatric disorders in adolescents and young adults with DS and other intellectual disabilities, Dykens et al 2015

Psychiatric and behavioral disorders in persons with DS, Dykens 2007 

Neurobehavioral disorders in children, adolescents and young adults with DS, Capone et al 2006

Disruptive Spectrum

Guanfacine Use in Children With DS and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) With Disruptive Behaviors, Capone et al 2016

Disruptive behavior in DS children: a cross-sectional comparative study, Yahia et al 2014

DS and attention deficit hyperactivity disorder (ADHD), Ekstein et al 2011

Maternal attribution of child noncompliance in children with MR: DS versus other causes, Ly, 2002 

Autism Spectrum  

Prevalence of ASD and ADHD in DS: Population-based study, Oxelgren et al 2016

Autism Characteristics and Behavioural Disturbances in ∼ 500 Children with DS in England and Wales, Warner et al 2014

Prevalence of ASD symptomatology and related behavioural characteristics in individuals with DS, Moss et al 2013 

ASD in DS: cluster analysis of ABC data supports diagnosis, Ji et al 2011

Screening for ASD in Children With DS: Population Prevalence and Screening Test Characteristics, DiGuiseppi et al 2010

Risperidone use in children with DS, severe ID, and comorbid ASD: A naturalistic study, Capone et al 2008

Difference in age at regression in children with autism with and without DS, Castillo et al 2008

Adolescent Regression 

Rapid clinical deterioration in an individual with DS Jacobs et al 2016

Down Syndrome Disintegrative Disorder: New-onset autistic regression, dementia and insomnia in older children and adolescents with DS Worley et al 2014

Developmental Regression, Depression and Psychosocial Stress in an Adolescent with DS. Stein et al. 2013

Atypical Loss of Attained Function in DS (Regression) Devenny 2011

Hashimoto's Encephalopathy and DS. Brodtmann 2009

Movement Disorders

Catatonia in DS: a treatable cause of regression Ghaziuddin, et al 2015