Clinical Trials in Cognition
Research Publications Full text articles from PubMed Central, links to NLM PubMed abstracts and additional resources are available from this page.
Clinical Trial Results
Vitamin E in aging persons with DS: A randomized, placebo-controlled clinical trial, 2016
Antioxidant intervention attenuates oxidative stress in children and teenagers with DS, 2014.
Prolonged coenzyme Q10 treatment in DS patients: effect on DNA oxidation, 2012.
DS and dementia: a randomized, controlled trial of antioxidant supplementation, 2011.
Effect of leucovorin (folinic acid) on the DQ of children with DS and influence of thyroid status, 2010
Supplementation with antioxidants and folinic acid for children with DS: randomised controlled trial, 2008.
Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21, 2007.
Coenzyme Q10 absorption and tolerance in children with DS: a dose-ranging trial, 2006.
The effect of acetyl-L-carnitine administration on persons with DS, 2006.
Effect of the chronic treatment with L-acetylcarnitine in DS, 1994
Piracetam therapy does not enhance cognitive functioning in children with DS, 2001
Epigallocatechin-3-gallate (EGCG) Green Tea Extract
Safety and efficacy of cognitive training plus epigallocechin-3-gallate in young adults with DS (TESDAD), 2016
Towards onset prevention of cognition decline in adults with DS (The TOP-COG study): A pilot randomised controlled trial, 2016
Clinical Trial Results
Donepezil significantly improves abilities in daily lives of female DS patients with severe cognitive impairment: a 24-week randomized, double-blind, placebo-controlled trial, 2011.
Donepezil for treatment of cognitive dysfunction in children with DS aged 10-17, 2010.
The efficacy, safety, and tolerability of donepezil for the treatment of young adults with DS, 2009
Dramatic improvement in DS-associated cognitive impairment with Donepezil, 2005.
Effects of donepezil on cognitive functioning in DS, 2003.
Donepezil for the treatment of language deficits in adults with DS: a preliminary 24-week open trial, 2003.
DS and Alzheimer disease: response to Donepezil, 2002.
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with DS and Alzheimer's disease--pilot study, 2002.
Safety and efficacy of rivastigmine in children with DS: a double blind placebo-controlled trial, 2016
Safety and efficacy of rivastigmine in adolescents with DS: long-term follow-up, 2010
Safety and efficacy of rivastigmine in adolescents with DS: a preliminary 20-week, open-label study, 2006.
Antagonism of NMDA receptors as a potential treatment for DS: a pilot randomized controlled trial, 2012.
Memantine for dementia in adults older than 40 years with DS (MEADOWS): a randomised, double-blind, placebo-controlled trial, 2012.